@WhoAteMeDinner: Yeah as Matt said I use a back-3. 3-5-2, two wingbacks, 1 DMF, 1 CMF, 1 AMF, two strikers. The challenge is extra-hard on PES6 because unlike on 2008, you don't have prospects like El Moubarki or Gutierrez who develop very well.
On the first seasons of the save, I always recommend to focus more on developing players, even if it means losing almost every match as a consequence. It's not like you're going to be promoted on season one (unless the stars align somehow) so try to play your younger players as much as possible, even if you end up rock bottom in the league. I'd say the first 2/3 seasons will serve no other purpose but to upgrade your players' stats (by the way make sure every pre-season you assign individual or collective training!).
I also recommend to focus on the D2 Cup, with a bit of luck and effort you could win precious PES points for your salaries by reaching the later rounds of the competition.
Now regarding the tactical approach...I'm with Matt there: Stein and Dodo should play together in the midfield, regardless of the tactic. They develop nicely, and are extremely reliable from the start. Also, to take proper advantage of Minanda, I'd find a way to play a classic nº10 behind the strikers (Ordaz and Hamsun?). Defensively, a back-3 exposes less of Jaric's poor aerial ability and makes Libermann shine as the central CB, as he has the protection of the two other CBs alongside him. On the wings, Espimas still has a lot to offer as either a RMF or a RWB and don't overlook Giersen, I'm on my season 8 and still I find him to be very useful and reliable.
@mattmid: You know, I've never tried this, but a low-stats/high mental stats league could take the experience to a whole new level really. It would mean more reliance on player intelligent/stability and less on player stats, and force you to play the game accordingly. Interested to see how that experience plays out, usually (always?) in PES the players have better statsheets as a whole, excluding mentality/teamwork, than those exact two stats. If you flip it upside down, what will you get?