The Regulate Condition feature has its advantages and disadvantages. The whole point of it is to affect the arrows that show what kind of form the player is in. I'm sure most people know that the better the arrow is, the better the player will play because positive arrows give your stat increases while negative ones give you a decrease.
But the problem with this is that it increases your level of fatigue which is bad for two reasons. Firstly it means that using it too much will get your players very tired and jaded up to the point where you cant afford to play them. And secondly, I've noticed that players with a high fatigue level see their stamina decrease a lot faster during the match itself.
IMO, you should only use this under two conditions.
a) If you have a must win game coming up and have a game after where you can afford to rest players.
b) If the player is a substitute cuz seeing how he wont be playing the full game, his stamina and fatigue wont be used as much as players who play the full 90 mins.
You can have exceptions but those two rules mainly apply to when you're thinking about using the Regulate Condition on the whole team rather than individual players. Its a slightly different case with individual players cuz lets say for example you have one striker and two very important players who support him, you're gonna need atleast one of them at the top of their game to help your striker so I usually like to alternate between them two every week. So one week I regulate the first players condition and then the second week I do the other player, and then keep switching every week. That way, whilst one player is getting tired, the other is recovering.