I started with a 5-4-1, backline: Shaw, Bailly, Hummels, Lindelof, Valencia. Two DMFs (Matic, Casemiro) in front of them, Martial on the left, Lingard on the right and Lukaku up front. Didn’t start Pogba despite his TS boost, mainly because he has this heavy touch and I needed quick and agile players in midfield as the first line of defense.
Offensive settings: counter, long pass, keep formation (you don't want players to run all over the place), support range high. The latter one is crucial when you need more addressees for cross-field passes during build-up. Before this I had this wrong all the time and lost a lot of balls in my own half, which is deadly, especially when the COM plays on red attack/defense.
Defensive settings: Frontline pressure, wide, aggressive, line and compactness both at 4.
For advanced instructions I pulled Lukaku back a bit (false 9) and set the other option to "Hug the Touchline".
Defensively, I went for "Deep Defensive Line" and alternated with "Gegenpress" before the goal and "Swarm the Box" after I scored. I also man-marked Jesus and Sterling.
I made the experience that when you play "Gegenpress" the ref whistles a lot of fouls in your favor, but you shouldn't play it towards the end, because it opens up your defense too much.